How to Effectively Improve the Effect of Tumor Chemotherapy by Microfluidic Technology

Multidrug resistance is one of the main reasons for the failure of tumor chemotherapy. It is still a great challenge to develop methods that can effectively reverse tumor multidrug resistance and improve the effect of tumor chemotherapy. One of the main reasons for tumor multidrug resistance is the overexpression of an ATP consuming transporter on the surface of cell membrane. They can actively pump various chemotherapeutic drugs out of cancer cells, resulting in the reduction of cytotoxicity of chemotherapeutic drugs. Among them, P-glycoprotein (P-gp) is an important protein. Apatinib is an inhibitor of P-gp. If apatinib can act on the P-gp protein on the tumor cell membrane first, the chemotherapeutic drugs entering the tumor cells can effectively avoid being pumped out of the cells and improve the chemotherapeutic effect on drug-resistant cells.

To solve these problems, the research group of Professor Zhou Shaobing of Southwest Jiaotong University successfully prepared bamboo like polymer fibers by using microfluidic electrospun micelles. Adriamycin loaded targeted polymer micelles were loaded into the hollow part of bamboo like structure through water phase, and apatinib was loaded into the solid part of the fiber through oil phase. Then the fiber device was locally implanted near the tumor tissue of tumor bearing mice The hollow part of the egg fiber breaks due to degradation and releases the targeted polymer micelles loaded with Adriamycin; the solid part of the fiber slowly degrades and releases apatinib. Apatinib diffuses into drug-resistant tumor cells and inhibits P-gp glycoprotein. The targeted micelles enter drug-resistant tumor cells through receptor-mediated endocytosis and release the chemotherapeutic drug adriamycin in the cytoplasm In addition, the device can significantly reduce the accumulation of drugs in normal tissues, so as to reduce the toxic and side effects of chemotherapy drugs.

How to Effectively Improve the Effect of Tumor Chemotherapy by Microfluidic Technology 1

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